In 1979, an American film crew disappears in the Amazon rainforest while filming a documentary about indigenous cannibal tribes. The team consists of Alan Yates, the director; Faye Daniels, his girlfriend and script writer; and two cameramen, Jack Anders and Mark Tomaso. Harold Monroe, an anthropologist at New York University, agrees to lead a rescue team in hopes of finding the missing filmmakers.
After trekking through the forest for several days, Monroe and his team reach the Ya̧nomamö, a cannibalistic tribe, who invite them back to their village, yet they treat the outsiders with suspicion. To gain their trust, Monroe bathes naked in a river. A group of Ya̧nomamö women emerge from the riverbank to take him to a shrine, where he discovers the rotting remains of the filmmakers. Angered, he confronts the Ya̧nomamö in the village, during which time he plays a tape recorder. The intrigued natives agree to trade it for the filmmakers' surviving reels of film during a cannibalistic ceremony, in which Monroe must take part.
Back in New York, executives of the Pan American Broadcasting System invite Monroe to host a broadcast of the documentary to be made from the recovered film, but Monroe insists on viewing the raw footage before making a decision. Can he find the cause behind the film crew's death? What will Monroe see in the recovered footage that disturbs him to the extent that he wonders who the cannibals really are, the native tribe or the so-called civilised crew members?