Embedded with disturbing violence and harsh reality, this socially relevant drama shockingly shows the trials and travails in the life of Agnes, a 14-year-old girl who is shouldered with the responsibility of caring for her two younger sisters. In a desperate attempt to send for her children, Agnes' mother, Sarah (Selma Blair) was forced into prostitution. To add to their woes Sarah comes under the complete control of an abusive pimp Duval (Bokeem Woodbine) who has gotten her addicted to alcohol and drugs.
The movie starts when Agnes arrives home, very early in the morning. She begins tidying the house and wakes Bee, after preparing her paper route for her. The conversation between the two reveals there is another sister, Cammie, and that Cammie often stays the night at her friend Sheila's house. The movie reveals that the girls and their mother once had a real family. Their father, a preacher, used to beat Sarah and the girls. The four fled, and Sarah, struggling to make ends meet, became a prostitute.
The day shifts from girl to girl. There is little interaction among the three. Bee speaks of moving into a foster home, hoping to be adopted. Cammie spends the day at a bar, making friends with Dolly (Natalie West), the bar owner, and Stymie (David Alan Grier), an alcoholic. Agnes rides through town, talking with a few friends, playing a game of basketball and picking up a couple of paychecks from her part-time jobs.
Towards the end of the day, Agnes climbs through Bee's window, avoiding the living room, which is full of gamblers, pimps and drunks. Bee has locked herself in her room and, like Agnes, avoids the downstairs chaos. Agnes makes Bee leave the house, telling her not to come back for a while. She then makes her way into the living room, and a stranger begins to talk to her.
He asks her why she is there, and she responds by telling him that this is where she lives and that Sarah was her mother. When the man finds out that Agnes is a star basketball player for her high school team with an important game that night, the man gives her a sympathetic look and tells her to get out of the house and go to the game, but she ignores him.
Later that evening, Duval and Agnes begin kissing again, Agnes narrates over the entire scene, after a few minutes Duval then rapes Agnes. As Duval releases her, she runs to the bathroom to clean herself, horrified by the thoughts of the violence and possibility of pregnancy. She is completely traumatized. Her mother enters the bathroom, and as Agnes reaches for her in utter distress, Sarah refuses to touch her and instead tells Agnes to go to the store to pick up alcohol after reminiscing on Agnes being a handful as a young child, showing intelligence even when she was a one-year-old.
Soon after, Agnes overhears Duval telling Sarah that he will begin pimping and selling Agnes as well. Agnes threatens to shoot Duval, firing a couple of shots to prevent Duval from leaving, screaming to her mother that he raped her and deserves to be shot for what he does to Sarah as well. Sarah only tells Agnes that she'll defend him. Agnes leaves for her basketball game.
After scoring 27 points in the second half alone, a record that lasts for years to come. Agnes fell when she was making the last goal and then leaves and limps to the car and has a meltdown. She then wipes her tears and puts the horrific events of the night in the back of her mind. She drives off and finds Bee and Cammie at a nearby bridge.
The two get in the car with Agnes not telling her young sisters of events that took place that evening, and instead takes them to get dinner. Bee reveals that she went to the bar after she went to a friend's house and that she found Cammie. Cammie then plays "Ain't No Mountain High Enough", and the movie closes as the three girls sing together.
At the start of the film credits, it reveals that Agnes left Iowa to go to New York and became an actress and artist. It also reveals that 20 years later she directed the movie, and that the movie is the true story of director and actress Lori Petty's childhood.